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CAS No. 100-15-2 represents one of the most critical aromatic nitro intermediates globally. As an essential precursor for pharmaceuticals (such as Acetaminophen/Paracetamol), organophosphorus crop protection agents, and specialty polyimide dyestuffs, maintaining strict molecular stability and trace-level impurity limits is paramount for chemical synthesis plants worldwide.
Industrial performance directly depends on the separation of ortho- and meta-isomers. Leading manufacturing facilities achieve an assay of ≥ 99.2% through continuous multi-stage fractional crystallization, securing isomer selectivity required for critical peptide synthesis and high-performance polymers.
Moisture contamination significantly alters reaction kinetics in condensation pipelines. By applying closed-loop fluid bed drying protocols, our manufacturing partners secure moisture levels ≤ 0.10%, preventing side-chain hydrolytic decomposition during international multimodal transit.
In accordance with global active pharmaceutical ingredient (API) safety thresholds, ignition ash residues are sustained below 0.05%, with trace metal impurities (Pb, As, Fe) suppressed within single-digit ppm thresholds via closed inert reaction pathways.
| Analytical Parameter | Guaranteed Industrial Grade | High-Purity Pharma Intermediate Grade | Standard Test Methodology |
|---|---|---|---|
| Chemical Name | 4-Nitrophenol / p-Nitrophenol (CAS No. 100-15-2) | IUPAC Nomenclature / Structural Verification | |
| Assay (GC / HPLC) | ≥ 99.0% | ≥ 99.5% | Gas Chromatography / High-Perf Liquid Chromatography |
| Melting Point Range | 112.0 – 114.5 °C | 113.5 – 115.0 °C | Capillary Melting Apparatus (ASTM E324) |
| Loss on Drying (Moisture) | ≤ 0.30% | ≤ 0.10% | Karl Fischer Coulometric Titration |
| Residue on Ignition (Ash) | ≤ 0.10% | ≤ 0.03% | Muffle Furnace Ashing at 800±25 °C |
| o-Nitrophenol Isomer | ≤ 0.20% | ≤ 0.05% | Capillary Column Chromatography (FID) |
Enterprise chemical procurement leaders face tight environmental oversight, container freight volatility, and continuous raw material inflation. China’s centralized production hubs deliver continuous scale economics backed by resilient supply chains.
Direct supply contracts backed by dedicated storage infrastructure minimize disruptions caused by regional power limits and raw material feed variability.
Integrated chemical synthesis from upstream chlorobenzene nitration down to downstream isolation delivers cost savings across long-term purchase agreements.
UN-approved Class 6.1 packaging (PG III, UN 1663) engineered to withstand maritime temperature shifts, backed by full IMDG/IATA declarations.
Standardized pre-shipment SGS / Intertek sampling capabilities alongside verified HPLC spectra ensure batch purity before vessel dispatch.
The manufacturing architecture of 4-Nitrophenol is transitioning from legacy batch processes to green continuous-flow microreactors. Discover how cleaner synthesis methodologies protect product yields and lower environmental footprints.
High-pressure continuous catalytic hydrolysis of 4-nitrochlorobenzene (PNCB) eliminates reactor hotspots, decreases wastewater toxicity by 42%, and narrows isomer output variations.
Melt crystallization platforms avoid organic solvents during purification, yielding dense crystalline flakes with minimal free moisture and zero lingering hydrocarbon residues.
Low-temperature vacuum stripping removes volatile organics to ≤ 10 ppm, meeting strict air-safety limits during downstream customer handling and storage.
Exporting toxic substances like 4-Nitrophenol demands strict regulatory diligence. Industrial suppliers must manage GHS-compliant communications, customs clearances, and safe handling procedures across North American, European, and Asia-Pacific terminals.
Shipments destined for European or Turkish facilities are backed by comprehensive REACH dossiers, ensuring continuous supply security without customs delays.
Material imported into North American regions is fully certified under the Toxic Substances Control Act (TSCA), supported by 16-section OSHA-compliant Safety Data Sheets (SDS).
Shipped in UN-certified steel drums (1A2) or reinforced composite fiber drums with anti-static polyethylene liners, ensuring zero cake formation during humid sea crossings.
Clear, technical answers addressing logistics, purity limits, and procurement parameters for CAS No. 100-15-2 sourcing.
The predominant manufacturing route involves the continuous alkaline hydrolysis of p-nitrochlorobenzene (PNCB) under controlled pressure and temperature, followed by acid precipitation, centrifugal washing, and multi-stage crystallization to remove residual ortho-isomers.
Under international UN Model Regulations, 4-Nitrophenol is classified as Class 6.1 (Toxic Substances), Packing Group III, UN Number 1663. Maritime shipping strictly adheres to the International Maritime Dangerous Goods (IMDG) Code with certified UN packaging.
Discoloration typically stems from oxidation and light exposure. Leading manufacturers utilize nitrogen-purged hermetic sealing within moisture-impermeable dual-layer liners, protecting the light-yellow crystal needles throughout multi-week ocean transit.
Yes. Specialized pharma-intermediate processing runs incorporate additional recrystallization loops and carbon adsorption steps, bringing total assay levels above 99.8% while suppressing individual organic impurities below 0.05%.
Supporting advanced industrial processes: discover our ultra-pure semiconductor carrier gases, specialty polymers, and industrial nitrates.
